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The show has now become closely associated with the city of Seattle, but it could have been set in a completely different area: Rhimes originally had her eyes set on New York, Boston or Philadelphia.'This is not a small town life.Big city, big medical center, big surgical opportunities,' the show runner initially wrote.Given that in season 9 it was confirmed that Meredith had test positive for certain genetic markers for the disease, and the fact that her mother, the awe-inspiring but terrible Ellis Grey, suffered from Alzheimer’s, this is, upsettingly, 100% plausible.will never end and we won’t have to figure any of this stuff.boss Shonda Rhimes hinted that more departures could be on the horizon following last May’s deadly cliffhanger — and she wasn’t kidding. Mark Sloan looked on in horror as his soul mate Lexie (Chyler Leigh) passed away from her own injuries suffered in the plane crash, has , ABC and Shondaland for the experience and memories I have had over the course of this run,” Dane tells TVLine exclusively.“It has been wonderful to work alongside and learn from a creative force such as Shonda Rhimes.” RELATED | Chyler Leigh Breaks Her Silence About She added that Dane “did not come to this decision lightly, but after much consideration and conversations, he and I have decided that this is the right time for his storyline to end.The sequence became one of the season’s biggest watercooler moments and led the hottie plastic surgeon to be dubbed “Mc Steamy.” It also prompted Rhimes to bring him back the following season as a full-time series regular.Mark was eventually sprung from the Addison-Derek-Meredith kerfuffle and began an on-again-off-again romance with Lexie — a relationship that ended tragically in last May’s Season 8 finale.

Surely, that would have given his romance with Meredith Grey an interesting twist.

Wilson then attended Harvard Medical School, where she graduated at the top of her class. Schmidt was the only person who supported her and thus the only one at her graduation.

During a conversation with Andrew De Luca, Jo revealed that she is married.

Although it is set in Seattle at the fictional Grey-Sloan Memorial Hospital (formerly Seattle Grace) it is primarily filmed in Los Angeles, California.

The show was originally titled Complications, a reference to the complicated medical procedures and personal lives of the characters. The original cast consisted of nine star-billed actors: Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington and Patrick Dempsey.

“We’re a big family here at with a long history together and Eric will always remain an important part of our family,” Rhimes continued.

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